Sure, BettyAnn! We haven't tried it ourselves but we don't see why not! We'd suggest trying it out once with about half the amount of cranberries in place of blueberries and we think roughly chopping them will be helpful too. For the orange zest, we'd suggest using the zest from half an orange. We also have a Blood Orange Cranberry Walnut Muffins recipe that you might like to check out! We hope this helps and happy baking! 

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