Hi Esther, Yes, you can use real buttermilk in place of buttermilk powder. The ratio is 1/4 cup of powder + 1 cup of water can be replaced by 1 cup liquid buttermilk. So, 2 tablespoons powder would be half of that, so you can replace 1/2 cup of the water in the recipe with liquid buttermilk. ~ MJ

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