Hi Matt, no, we don't recommend substituting this flour for other gluten-free flours in this way. In addition, our test kitchen hasn't developed any bread machine recipes utilizing our GF Bread flour and is still reluctant to recommend using it with a bread machine, although they did offer this suggestion if you wanted to use the bread machine for the mixing portion of the recipe: you could try custom settings of 1 minute of mixing, 20 minute rest, 1 minute mixing, 1 minute rest, then knead dough by hand and bake in your home oven. For best results, we recommend following one of the recipes we have already developed for this flour and utilizing the rising and baking instructions for these recipes. 

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